Sos1 Pure 25/SOS1 150ug

• 产品编号：BD-610096      品牌：BD-Pharmingen       原厂货号：610096
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The
Sos (sonofsevenless)
gene was originally identified in
Drosophila,
and two mammalian homologues (
mSos1
 and
mSos2
) were isolated
from a mouse cDNA library. These two cDNAs predict proteins that are approximately 70% identical in their amino acid residues. Both
mSos1
and
mSos2
 are expressed in a wide number of mouse embryonic and adult tissues as well as in several cell lines. The human homologues,
hSos1
 and
hSos2
 have also been isolated and show a very high degree of amino acid identity to the mouse genes (98% for Sos1). Sos1 has a
predicted molecular weight of 150kDa, but the apparent molecular weight is closer to 170 kDa, presumably due to a high proline content. The
mammalian Sos1 protein has a highly specific guanine nucleotide exchange activity toward p21ras . In EGF-stimulated cells, Sos1 interacts
with the SH3 domains of GRB2, and GRB2 binds via its SH2 domain to tyrosine 1068 of the activated EGF receptor. Thus, GRB2 recruits
Sos1 to the plasma membrane and enables it to activate the Ras signaling pathway by enhancing GTP loading on p21ras .

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at -20°C .