Hu IFN-Gma BV786 4S.B3 50Tst

产品编号：BD-563731 品牌：BD-Pharmingen 原厂货号：563731
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

50Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The 4S.B3 monoclonal antibody specifically binds to interferon-γ

(IFN-γ). The immunogen used to generate this hybridoma was partially

purified human IFN-γ

obtained from supernatants of human PBMC stimulated with

Staphylococcus aureus. Interferon-γ(IFN-γ) is a potent

multifunctional cytokine that is produced by several activated cell types including NK, NKT, CD4+TCR

αβ+, CD8+TCRαβ+, and TCRγδ+ Tcells. IFN-γexerts its biological effects through specific binding to the high-affinity IFN-γReceptor Complex comprised of IFN-γRα(CD119)and IFN-γRβ

subunits. In addition to its antiviral effects, IFN-γ

upregulates a number of lymphoid cell functions including the antimicrobial

and antitumor responses of macrophages, NK cells, and neutrophils. In addition, IFN-

can exert strong regulatory influences on the

proliferation, differentiation, and effector responses of B cell and T cell subsets. These influences can involve IFN-γ’s capacity to boost MHC

class I and II expression by antigen-presenting cells as well as to direct effects on B cells and T cells themselves. Human IFN-γis a 14-18 kDa

glycoprotein containing 143 amino acid residues.

The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. This dye is a

tandem fluorochrome of BD Horizon™ BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 786-nm. BD Horizon™

BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60-nm filter).

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.