Hu CD39 BV421 TU66 100Tst

产品编号：BD-563679 品牌：BD-Pharmingen 原厂货号：563679
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

100Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The TU66 monoclonal antibody reacts with human CD39 also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) an

ectoenzyme that degrades ATP to AMP. It is a member of the family of ectonucleoside triphosphate dihydrolases (E-NTPDases) known to be

involved in regulation of extracellular nucleotide catabolism, controlling the extracellular nucleoside triphosphate pool (NTP). CD39 is

expressed on a subset of T cells, B cells and dendritic cells with weak staining of monocytes and granulocytes. Recently, CD39 has been

found to be expressed primarly by immune-suppressive Foxp3(+) regulatory T (Treg) cells in both human and mice. In humans, CD39 is

restricted to a subset of Foxp3+ regulatory effector/memory-like T cells. In mice, the enzyme is present on most if not all CD4+CD25+ cells

and CD39 expression is driven by Foxp3. It is thought that CD39 allows Treg cells to enter inflamed areas where high levels of ATP are

present.

The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. With an Ex Max

of 407-nm and Em Max at 421-nm, BD Horizon™ BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter

set (eg, 450/50-nm filter). BD Horizon™ BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared

to Pacific Blue™ conjugates.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.