Ms Blimp-1 Alexa 647 5E7 50ug

产品编号：BD-563643 品牌：BD-Pharmingen 原厂货号：563643
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

50ug

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The 5E7 monoclonal antibody specifically binds to mouse B lymphocyte-induced maturation protein 1 (Blimp-1). Blimp-1 is a 98 kDa zinc

finger-containing protein that is encoded by the

Prdm1

gene and functions as a transcriptional repressor. Blimp-1 is essential for regulating the

terminal differentiation of activated B cells into plasma cells. In this process, Blimp-1 suppresses genes involved in B cell proliferation, such as Myc and Bcl6. It controls other genes, such as Xbp1

, that are required for upregulating the plasma cell’s protein synthesis machinery which

is essential for antibody production and secretion. Blimp-1 is an important regulator in other cell types as well. It functions in the regulation of

T cell activation and homeostasis and NK cell maturation. Blimp-1 is expressed in activated T cells and can function to inhibit IL-2 production

while enhancing the differentiation and expression of several molecules produced by effector T cells.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.