Hu ROR Gma T Alexa 647 Q21-559 50Tst

产品编号：BD-563620 品牌：BD-Pharmingen 原厂货号：563620
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

50Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The Q21-559 monoclonal antibody recognizes ROR gamma t (RORγ

t), an isoform of ROR gamma (RORγ). RORγ

t is a DNA-binding

transcription factor that is encoded by the

RORC

(RAR-related orphan receptor C) gene. It belongs to the ROR/RZR orphan nuclear receptor

family. Two protein isoforms are produced from the

RORC

gene by alternative splicing: RORγ

or RORγ

t. The RORγ

isoform is expressed in

many tissues, including thymus, lung, liver, kidney, muscle, and brown fat. However the tissue distribution of the second isoform RORγ

t is

highly restricted to the thymus where it is expressed exclusively in immature CD4+CD8+ thymocytes and in peripheral Th17 and LTi cells.

RORγ

t reportedly functions as an essential transcription factor for the development of secondary lymphoid tissues. It also plays an important

regulatory role in thymopoiesis and effector T cell differentiation, especially for Th17 cells.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.