Hu Lin-28 Alexa 488 6D1F9 50Tst

• 产品编号：BD-563597      品牌：BD-Pharmingen       原厂货号：563597
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

Lin-28 is an evolutionarily conserved RNA-binding protein that is expressed in embryonic tissue, embryonic stem cells, and some adult tissues
(e.g. cardiac and skeletal muscle). Within these cells, it is localized to ribosomes, P-bodies, and stress granules. During embryonic
development, Lin-28 acts as a "translational enhancer" by binding to certain mRNAs and increasing their translation efficiency. Additionally,
Lin-28 is overexpressed in some human cancer cell lines and is associated with the malignant transformation of cells as well as advanced
human malignancies. This role is thought to be tied to the binding of Lin-28 to pre-microRNA of let-7, which in its mature form promotes
terminal differentiation of stem cells and suppresses tumors. The binding of Lin-28 to the immature version of let-7 blocks its cleavage into
mature microRNA, thereby preventing it from carrying out its function in tumor suppression. Lin-28, in combination with additional factors,
has been used to reprogram human somatic cells into induced pluripotent stem cells.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.