mTOR (pS2448) PE O21-404 50Tst

产品编号：BD-563489 品牌：BD-Pharmingen 原厂货号：563489
产品分类：抗体 > 一抗 > 磷酸化抗体
应用分类：

包装：

50Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The O21-404 monoclonal antibody recognizes the human mammalian target of rapmycin,(mTOR) that is phosphorylated at

serine residue 2448, mTOR (pS2448). mTOR belongs to the phosphoinositide-3-kinase (PI3K)-related (PIKK) family of kinases. mTOR is

also known as mechanistic target of rapamycin (serine/threonine kinase), FRAP, RAFT1, and RAPT1. mTOR functions as an amino acid and

ATP sensor to balance nutrient availability and cell growth. When nutrients are sufficiently available, mTOR is activated by phosphorylation

at serine residue 2448 through the PI3 kinase/Akt signaling pathway. Phosphorylated mTOR in turn activates the p70 S6 kinase and

contributes to the inactivation 4E-BP1, an elF4E inhibitor. In this way, mTOR participates in the upregulation of cellular protein synthesis,

growth, proliferation and survival. mTOR function may be abnormally regulated in tumors.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.