Hu CD172a/b PE SE5A5 100Tst

产品编号：BD-563441 品牌：BD-Pharmingen 原厂货号：563441
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

100Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The SE5A5 monoclonal antibody specifically binds to a common epitope on CD172a/SIRP α

(90 kDa) and CD172b/SIRP β (50 kDa). These

transmembrane glycoproteins are members of the Signal Regulatory Protein (SIRP) family that, in turn, belongs to the Immunoglobulin

superfamily. The SIRP family is comprised of two subgroups, SIRP α

and SIRP β

that are distinguished by the presence (α) or absence (β) of a

cytoplasmic domain containing two immunoreceptor tyrosine-based inhibition motifs (ITIM). CD172a/SIRP α

is expressed on CD34+

stem/progenitor cells, cardiomyocytes, monocytes, macrophages, granulocytes, dendritic cells, and in the central nervous system. It binds to

CD47 and is implicated in mediating inhibitory signals via the ITIM/SHP-2 association. SIRP

does not possess a cytoplasmic domain but

instead the transmembrane domain contains a positively-charged residue that can interact with another transmembrane protein,

DAP-12/KARAP. DAP-12 has two immunoreceptor tyrosine-based activation motifs (ITAM) within its cytoplasmic domain that are thought

to link SIRP β

to cellular activation signaling. SIRP β

is expressed on myeloid cells, including peripheral blood monocytes and granulocytes. It

is not expressed on CD34+ cells. SIRP α and SIRP β

have complementary roles in signal regulation and may work together in tuning certain

cellular responses to stimuli.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.