Hu CD238 PE BRIC 203 50Tst

• 产品编号：BD-563122      品牌：BD-Pharmingen       原厂货号：563122
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

The BRIC 203 monoclonal antibody specifically binds to the Kell blood group antigen, Kp(a-b+) but not Kp(a+b-), also known as the Kell
blood group metallo-endopeptidase, KELL, ECE3 and CD238. CD238 is an approximately 115-kDa type II transmembrane glycoprotein that
is encoded by the KEL gene. CD238 functions as a zinc endopeptidase that cleaves endothelin-3 into an active form which can function as a
vasoconstrictor. CD238 is expressed on erythrocytes, human embryonic stem cell-derived endoderm and on cells from various other tissues,
including testis, heart, brain and skeletal muscle. Decreased expression of CD238 is associated with the McLeod phenotype as a consequence
of losing XK protein expression. Kell antigen expression can play an important role during blood transfusions and also specific autoimmune
diseases related to Kell antigen recognition. During development the BRIC 203 monoclonal antibody was found to detect the CD238 antigen
by flow cytometric analysis of human erythrocytes. It reportedly works in immunoprecipitation and agglutination assays.
 

原厂资料：

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.