Hu CD278 BV421 DX29 50Tst

产品编号：BD-562901 品牌：BD-Pharmingen 原厂货号：562901
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

50Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The DX29 monoclonal antibody specifically binds to human CD278 which is also known as inducible costimulator (ICOS) and inducible
T-cell co-stimulator. ICOS is a homodimeric type I transmembrane glycoprotein with an approximate molecular weight of 50-60 kDa. It is a
member of the CD28 family and is highly expressed on activated T cells. CD278 is the receptor for ICOS-ligand (also known as CD275,
B7-H2, B7RP-1, and LICOS). Like CD28, ICOS can provide a costimulatory signal for T cell activation, proliferation and cytokine
production. It is not expressed on resting or activated B cells, monocytes, NK cells, granulocytes, dendritic cells or platelets. Unlike the
constitutively expressed CD28, ICOS is de novo expressed upon cellular activation. Reports describe similarities between CD28 and ICOS in
T cell activation, such as the costimulation of cytokine production. However, it has been suggested that ICOS may play a greater role in IL-10
production. In the presence of IL-10, purified recombinant human ICOS protein significantly increased in vitro B cell growth stimulated by
pokeweed mitogen (PWM) and enhanced production of IgG.
The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. With an Ex Max
of 407-nm and Em Max at 421-nm, BD Horizon™ BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter
set (eg, 450/50-nm filter). BD Horizon™ BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to
Pacific Blue™ conjugates.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.