Ms Siglec-F A647 E50-2440 50ug

• 产品编号：BD-562680      品牌：BD-Pharmingen       原厂货号：562680
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

The E50-2440 antibody reacts with Siglec-F, the sixth siglec protein to be reported in the mouse. Siglecs are the sialic acid-binding
immunoglobulin superfamily lectins defined in the human, each of which has a distinctive expression pattern in the hematopoietic system and
at least some of which are known to mediate cell-cell interactions. Orthologous proteins of human Siglec-1 (Sialoadhesin or CD169), Siglec-2
(CD22), and Siglec-4 (myelin-associated glycoprotein) have been characterized in the mouse. Human Siglec-3 (CD33) and Siglecs-5 through
-10 are encoded by a cluster of closely related genes, and each has two cytoplasmic ITIM (Immunoreceptor Tyrosine-based Inhibitory Motifs).
Similarly, mouse Siglec-F is encoded by a gene in a syntenic cluster in the mouse, and the protein has sialic acid-binding activity and an
intracytoplasmic ITIM. Its expression pattern differs from those of the human Siglec-3-related proteins in that it is found on immature cells of
the myelomonocytic lineage, with reduced expression on mature neutrophils and monocytes, and not on lymphoid cells. It has been proposed
that mAb E50-2440 may be used for identification of immature myelomonocytic cells in the mouse.
 

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.