Bta-Catenin Alexa 488 14 100Tst

• 产品编号：BD-562505      品牌：BD-Pharmingen       原厂货号：562505
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

The 14/Beta-Catenin monoclonal antibody specifically binds to Beta-Catenin (β-Catenin). β-Catenin is a 92 kDa protein that binds to the
cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula
adherens). Deletions in the cytoplasmic domain of E-Cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating
that this binding is essential for E-Cadherin function. Although the α- and β-Catenins have been cloned, very little is known about their
biochemical roles. However a link between β-Catenin and colon cancer has been described. β-Catenin was found to co-immunoprecipitate
with the APC tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells. E-Cadherin, however, was
not detectable in these complexes. Thus the APC-Catenin complex may be affecting the transmission of contact inhibition signals and/or the
regulation of cell adhesion.

原厂资料：

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.