Hu CD73 Horizon V450 AD2 50Tst

• 产品编号：BD-561255      品牌：BD-Pharmingen       原厂货号：561255
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

The AD2 monoclonal antibody specifically binds to ecto-5’-nucleotidase, a 70 kDa, glycosyl phosphatidylinositol (GPI)-anchored
glycoprotein. CD73 is expressed on bone marrow derived multipotent mesenchymal stem cells (MSCs), also sometimes identified as
mesenchymal stem cells, and is one of the three positive markers that has been identified by the International Society for Cell Terapy (ISCT)
for the minimum criteria for identifying MSCs. Additionally CD73 is expressed on subsets of T and B lymphocytes, follicular dendritic cells,
epithelial cells, and endothelial cells. Its expression on lymphocytes increases during T and B cell development. CD73 has enzymatic activity
and catalyzes the dephosphorylation of adenosine monophosphate (AMP) converting it to adenosine. It has been suggested that CD73 can
mediate costimulatory signals in T cell activation and adhesion of lymphocytes to endothelium. Due to the expression characteristics of this
molecule on different cell types, this BD Horizon™ V450 format is only recommended for use on cells expressing high amounts of CD73,
such as MSCs.
The antibody is conjugated to BD Horizon™ V450, which has been developed for use in multicolor flow cytometry experiments and is
available exclusively from BD Biosciences. It is excited by the Violet laser Ex max of 406 nm and has an Em Max at 450 nm. Conjugates with
BD Horizon™ V450 can be used in place of Pacific Blue™ conjugates.
 

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.