Hu TLR9 APC eB72-1665 100Tst

• 产品编号：BD-560428      品牌：BD-Pharmingen       原厂货号：560428
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

Toll-like receptor 9 (TLR9), also designated as CD289, is a type 1 transmembrane glycoprotein (~110-119 kDa calculated molecular weights
for protein isoforms) encoded by the TLR9 gene in chromosome 3. TLR9 is a member of the Toll-like receptor (TLR) family whose members
play fundamental roles in pathogen recognition and activation of innate immunity. TLR9 is highly expressed by plasmacytoid dendritic cells
and B cells and at lower levels in some other cell types. TLR9 is expressed predominantly in the endoplasmic reticulum. It is recruited to
endosomal and lysosomal compartments upon cellular stimulation by bacterial, viral or synthetic DNA molecules that contain unmethylated
CpG dinucleotide sequences. TLR9 generated signals lead to the activation of genes that express type-I interferons and proinflammatory
cytokines including IL-6 and IL-12. TLR9-mediated signaling is also implicated in acquired immune responses as well as in the pathogenesis
of autoimmune diseases. The eB72-1665.1 mAb recognizes the human TLR9 epitope from the peptide sequence, amino acids 273-288.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.This APC-conjugated reagent can be used in any flow cytometer equipped with a dye, HeNe, or red diode laser
3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
4.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
5.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
6.The antibody was conjugated to APC under optimum conditions, and unconjugated antibody and free APC were removed.