The M55-312 monoclonal antibody reacts with mouse Nanog (named for Tir Na Nog, the land of the ever-young of Celtic mythology), which
is a homeobox transcription factor required for the maintenance of the undifferentiated state of pluripotent stem cells. Nanog expression
counteracts the differentiation-promoting signals induced by the extrinsic factors LIF (Leukemia Inhibitory Factor) and BMP (Bone
Morphogenic Protein). When Nanog expression is down-regulated, cell differentiation can proceed. Proteins that regulate Nanog expression
include transcription factors Oct4, SOX2, FoxD3, and Tcf3 and tumor suppressor p53.
原厂资料:
注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.