p53 (acK382) Alexa 647 L82-51 50Tst

产品编号：BD-560231 品牌：BD-Pharmingen 原厂货号：560231
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

50Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The p53 protein is critical to regulation of normal cell growth and proliferation and is a suppressor of tumor cell proliferation. Inactivation of
p53 by a number of mechanisms, such as missense mutations or interaction with oncogenic viral or cellular proteins, can result in tumor
progression. Mutations and/or allelic loss of the p53 gene are associated with a wide variety of human tumors. Known to have a role in
transcriptional regulation, p53 suppresses various promoters containing TATA elements in an apparently sequence-independent fashion. p53
also binds to DNA in a sequence-specific manner via recognition of a 20-bp consensus-binding site. This interaction stimulates the expression
of genes downstream of the p53 binding site. A number of genes that contain p53-binding sites have been identified, including MDM2,
GADD45, and muscle creatine kinase. Post-translational acetylation of p53 enhances its DNA-binding activity. There are multiple factors
that affect p53 acetylation, thereby modulating cellular proliferation and apoptosis.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results..
3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
4.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.