Noggin Pure L98-788 100ug

产品编号：BD-560170 品牌：BD-Pharmingen 原厂货号：560170
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

100ug

运保温度:

Store undiluted at 4°C.

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描述：

The L98-788 monoclonal antibody reacts with noggin glycoprotein, a secreted antagonist of the bone morphogenic proteins (BMPs). Noggin
homodimers block the binding of BMPs to their receptors. The phenotypes of natural noggin mutations in humans (such as symphalangism
proximal syndrome, synostoses syndrome 1, and brachydactyly type B2) and noggin-null mice indicate that noggin regulates cartilage and joint
formation. Noggin is also involved in neural tube, somite, and myocardial morphogenesis and osteoblastic/osteoclastic responses to metastatic
cancers. Noggin is highly conserved in vertebrates; the amino-acid sequence identities of human noggin with mouse, rat, bovine, equine,
chicken, and frog (Xenopus) noggin are 99%, 99%, 98%, 97%, 89%, and 81%, respectively.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.