Ms IL-17A PE TC11-18H10 100ug

产品编号：BD-559502 品牌：BD-Pharmingen 原厂货号：559502
产品分类：抗体 > 一抗 > 染料标记抗体
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包装：

100ug

运保温度:

4°C

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描述：

TC11-18H10抗体可与重组的和天然小鼠的IL-17A蛋白发生反应。IL-17A也称为CTLA-8，是T细胞来源的细胞因子，具有促进炎症反应的能力。小鼠IL-17A是促炎性细胞因子，可诱导小鼠基质细胞释放IL-6。在体外，IL-17A可维持造血祖细胞的生长；在体内，它可刺激粒细胞生成。TC11-18H10抗体可中和IL-17A的活性。研究表明，IL-17A是由Th17细胞的一个单一亚群产生，该细胞亚群的发生途径不同于Th1细胞与Th2细胞的分化途径。小鼠IL-17A的cDNA来自TCRαβ+ CD4-CD8-胸腺细胞的cDNA文库。

原厂资料：

The TC11-18H10 antibody reacts with recombinant and natural mouse IL-17A proteins. IL-17A, also known as CTLA-8, is a T cell-derived cytokine that promotes inflammatory responses. Mouse IL-17A is a proinflammatory cytokine that can induce the release of IL-6 by mouse stromal cells. It has been shown to support the growth of hemopoietic progenitors in vitro; it can also stimulate granulopoiesis in vivo. The TC11-18H10 antibody has been reported to neutralize IL-17A activity. Recent studies have shown that IL-17A is produced by a unique subset of Th17 cells that develop along a pathway distinct from the Th1- and Th2- cell differentiation pathways. The mouse IL-17A cDNA was isolated from a cDNA library generated from TCRαβ+CD4-CD8-thymocytes.

注意事项：

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.