Hu NPM-ALK/ALK Pure ALK1 100ug

产品编号：BD-559254 品牌：BD-Pharmingen 原厂货号：559254
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

100ug

运保温度:

Store undiluted at 4°C.

到货周期：

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描述：

Reacts with NPM-ALK, a chimeric gene product of approximately 80 kDa, which is the result of t(2;5)(p23;q35) chromosomal translocation.
The gene at 5q35 encodes for the cell cycle-regulated nuclolar protein nucleophosmin (NPM), and the gene at 2p23 encodes a novel receptor
tyrosine kinase, anaplastic lymphoma kinase (ALK). The 2;5 translocation results in the expression of NPM-ALK protein, or p80, comprised
of the N-terminal portion of NPM (about 40% of the molecule) linked to the entire intracellular portion of ALK. ALK1 antibody recognizes a
formalin resistant epitope in both the NPM-ALK chimeric and the 200 kDa normal human ALK proteins. Cytoplasmic and nuclear expression
of NPM-ALK is seen in t(2;5)+ cell lines SU-DHL-1 and Karpas 299.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Store undiluted at 4°C.