GM130 Alexa 647 35/GM130 100Tst

产品编号：BD-558712 品牌：BD-Pharmingen 原厂货号：558712
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

100Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

Maturation and post-translational modification of proteins occurs after their biosynthesis at the endoplasmic reticulum and their transport
through the Golgi apparatus. The process involves the transport of vesicles carrying the proteins through a vectorial process of vesicle budding
and fusion from the cis-compartment to the medial-compartment and the trans-compartment of the Golgi apparatus. The detergent insoluble
fraction of the Golgi is named "matrix" and is required for proper morphology of the Golgi membranes. GM130 (Golgi matrix protein of 130
kDa) is a protein isolated from the Triton™ X-100-insoluble Golgi matrix and peripherally associated with the cis-compartment, as
demonstrated by co-localization with syntaxin5. GM130 is homologous to the Golgi autoantigen golgin 95. GM130 interacts through its
N-terminal domain with p115 and with the Golgi membranes at the C-terminal portion. Furthermore, the mitotic phosphorylation of GM130
blocks the interaction with p115. Thus, GM130 appears to function as a structural element of the Golgi apparatus that also provides
attachment sites for membranes and other Golgi proteins. The 35/GM130 monoclonal antibody recognizes GM130, regardless of
phosphorylation status.

注意事项：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.