Hu CD64 PE 10.1 100Tst

• 产品编号：BD-558592      品牌：BD-Pharmingen       原厂货号：558592
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

10.1单克隆抗体特异性结合CD64。CD64是一个75 kDa的I型跨膜糖蛋白，是人IgG（FcγRI），特别是IgG1和IgG3的亚类的高亲和性受体。CD64表达于被干扰素-γ和早期骨髓谱系细胞激活的单核细胞、巨噬细胞、树突状细胞、粒细胞。CD64与一个FcRγ的同型二聚体形成高亲和力的FcγRI复合物。CD64在先天性和适应性免疫应答都有作用，还可介导内吞作用、吞噬作用、抗体依赖性细胞毒作用、细胞因子的释放和超氧化物的产生。

原厂资料：

The 10.1 monoclonal antibody specifically binds to CD64, a 75 kDa type I transmembrane glycoprotein that is a high affinity receptor for human IgG (FcγRI), especially the IgG1 and IgG3 subclasses. CD64 is expressed on monocytes, macrophages, dendritic cells, granulocytes activated with interferon-gamma and early myeloid lineage cells. CD64 associates with a signaling FcRγ homodimer to form the functional high affinity FcγRI complex. CD64 functions in both innate and adaptive immune responses and mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine release and superoxide generation.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental sample (a test).
2. Since applications vary, each investigator should titrate the reagent to obtain optimal results.

3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.