TBK1 (pS172) Pure J133-1171 100ug

• 产品编号：BD-558397      品牌：BD-Pharmingen       原厂货号：558397
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

NF-kB is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory,
viral, and acute phase responses. In most cells, NF-kB is sequestered in an inactive cytoplasmic form via interactions with the inhibitory
proteins IkBα, IkBβ, and IkBε. Stimulation induces the release, activation, and nuclear translocation of NF-kB. Release of NF-kB results
from the phosphorylation and proteolytic degradation of the IkB proteins. Two cytokine-inducible IκB kinases (IKKa and IKKb)
phosphorylate and target the IkB proteins for degradation via the ubiquitin pathway. IKKg/NEMO, a third member of the IKK complex,
functions as a regulatory subunit and interacts directly with IKKb. TBK1 (TANK-binding kinase 1, also known as T2K or NAK), a protein
of 729 amino acids, is another member of the IKK family of kinases regulating NF-kB downstream of the tumor necrosis factor and Toll-like
receptor pathways. TBK1 forms a complex with the adaptor proteins TANK (TRAF-associated NF-kB activator) and TRAF2
(TNF-receptor-associated factor 2), and this oligomer is required for activation and phosphorylation of TBK1 at serine 172 (S172).

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at 4°C .