Reacts with CD208, also known as DC-LAMP or lysosome associate membrane protein. DC-LAMP is an intracellular molecule, of approximately 70 - 90 kDa, induced during dendritic cell (DC) maturation. It is undetected in immature DCs, but it is sharply expressed upon activation with LPS, TNFa, or CD154 in DCs from skin, tonsil, cultures of CD34+ cells in presence of GM-CSF and TNFa, and on monocyte cultures in the presence of GM-CSF and IL-4. Reports describe the transient expression of CD208 in the MHC class II compartment before the translocation of the MHC II molecules to the cell surface. It has been suggested that the biological role of DCLAMP could be its participation in peptide loading onto MHC class II.
原厂资料：
注意事项：
1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 X 10e6 cells in a 100-μl experimental sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
5.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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