In the mouse, five homologues to human CD209 (DC-SIGN) have been described. Clone 5H10 antibody binds with CD209a, or CIRE, which
is the most closely related homologue to DC-SIGN. CD209a is a 238-amino-acid type-II transmembrane C-type lectin, with an extracellular
carbohydrate recognition domain, that is almost exclusively expressed on subpopulations of splenic CD8-negative dendritic cells (DC), splenic
plasmacytoid pre-DC, and resident peritoneal DC. Like human DC-SIGN, the mouse homologue binds to HIV and human ICAM-3 in vitro.
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注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.