Hu CD127 PE hIL-7R-M21 100ug

产品编号：BD-557938 品牌：BD-Pharmingen 原厂货号：557938
产品分类：抗体 > 一抗 > 染料标记抗体
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包装：

100ug

运保温度:

Store undiluted at 4° C

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描述：

单克隆抗体hIL-7R-M21可与60-90 kDa的糖蛋白CD127发生反应。CD127也称为IL-7受体α（IL-7Rα）。该受体是一种由CD127和γ链组成的异二聚体，其中γ链也由其它细胞因子受体（IL-2R、IL-4R、IL-9R和IL-15R）所共享。CD127表达于胸腺细胞、T细胞和B细胞的祖细胞、成熟T细胞，以及某些淋巴细胞和骨髓细胞。体外实验表明T细胞活化后，可导致CD127的表达下调。研究表明，IL-7受体在成熟T细胞的增殖和分化过程中起重要作用。最近有研究表明，CD127在细胞表面的低表达，与CD25（IL-2受体的α链）在细胞表面的高表达相结合，可区分人类成人和脐带血、淋巴结和胸腺的调节性和常规的CD4+T细胞。

原厂资料：

Monoclonal antibody hIL-7R-M21 reacts with the 60 - 90 kDa glycoprotein, CD127. CD127 is also known as the IL-7 receptor alpha (IL-7Rα). The receptor is a heterodimer composed of the CD127 and the common gamma chain, shared by other cytokine receptors (IL-2R, IL-4R, IL-9R, and IL-15R). CD127 is expressed on thymocytes, T- and B-cell progenitors, mature T cells, and some lymphoid and myeloid cells. In vitro experiments show the expression of CD127 is down-regulated following T cell activation. Studies indicate that the IL-7 Receptor plays an important role in the proliferation and differentiation of mature T cells. Recently, it has been shown that low surface expression of CD127, in combination with intermediate to high suface expression of CD25, the α chain of the IL-2 receptor, can distinguish between human regulatory and conventional CD4+ T cells in human adult and cord blood, lymph nodes and thymus.

注意事项：

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.