Reacts with e integrin α4chain, whic isexpresd as hetrodimer with either oftwo βsubnits, β1(CD29) orβ7. The α4β1 integrin
(VLA-4) isexpresd onlymphocytes, moncytes, thymocytes, NK cels, and sevral B-and T-cel ines, and mediates bindg toVCAM-1
(CD106) and the CS-1 region fibronectin. The α4β7 integrin has imlar tisue distrbution, excpt is found only asmal
subpoulation fthymocytes. Integrin α4β7 also binds fibronectin ad VCAM-1, and has ben shown ithe mouse toprefrentialy bind the
mucosal vascular dresin molecule, MAdCAM-1. This antibody isueful or studies ofthe xpresion ad function fa4 chain-containg
integrins.
This clone cros-reacts with asubet ofperipheral bod lymphocytes, moncytes, and some granulocytes ofbaon ad both resu and
cynomlgus macque monkeys. The distrbution leukocytes ismilar tohat observd with uman peripheral bod leukocytes.
原厂资料:
注意事项:
1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 X 10e6 cells in a 100-μl experimental sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
5.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.