Hu p16INK4 FITC Set G175-1239 100Tst

产品编号：BD-556560 品牌：BD-Pharmingen 原厂货号：556560
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

100Tst

运保温度:

Store undiluted at 4°C

到货周期：

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其它组分：

FITC Mouse Anti-Human p16【子货号：51-13384X，包装：100 tests (1 ea)，，运保温度：4°C】

描述：

Cyclins and cyclin-dependent kinases (cdks) form active complexes that regulate key events during the progression of the cell cycle and are
evolutionarily highly conserved. The p16 protein has been identified as a specific inhibitor of cdk4 because it blocks cdk4 substrate
phosphorylation. p16 inhibits cdk4 dependent phosphorylation of the tumor suppressor retinoblastoma protein (Rb) and Rb related proteins,
p107 and p130. The biochemical properties of p16 suggest that it may be a tumor suppressor gene product. Recently a gene cloned from the
short arm of human chromosome 9, Multiple Tumor Suppressor 1 (MTS1) has been identified as the gene for p16]. The gene, now also known
as the CDKN2 gene, has been found to be mutated in a very high percentage of tumors, including 75% of melanoma cell lines. Alternate names
for p16 include p16-INK4, p16-INK4a, ARF, MTS1, CDKN2, CDK4l.

注意事项：

1.This antibody has been optimized and preassayed with its matched isotype control to be used at the recommended volume of 20 ul/test.
Titration of the reagents or substituting with other (non-matched) isotype control is NOT recommended.

2.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
3.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
4.The antibody was conjugated withFITC under optimum conditions, and unconjugated antibody and free FITC were removed