Ms Id2 Pure B31-1 100ug

• 产品编号：BD-556523      品牌：BD-Pharmingen       原厂货号：556523
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Id proteins were originally characterized as inhibitors of DNA binding and cell differentiation. Id1 through 4 contain an evolutionarily
conserved helix-loop-helix (HLH) sequence which is critical for protein-protein interaction(s). Most HLH transcription factors contain a basic
amino acid region adjacent to the HLH sequence, the bHLH sequence, which is responsible for DNA binding. bHLH transcription factors fall
into 2 major groups designated class A factors, e.g., E2.2 and E47, and class B factors, e.g., MyoD, myogenin. In vitro studies demonstrate
distinct interaction(s) between Id proteins and bHLH transcription factors. While Id proteins contain an HLH domain, they lack the basic
region which is required for DNA binding. Therefore, Id proteins are negative regulators of transcription since complexes which contain them
do not bind DNA. Id proteins are variably expressed throughout the cell cycle and are regulated by phosphorylation by cyclin-cdk complexes.
Thus, Id proteins play an important role in transcriptional regulation of cell cycle related genes. Overexpression of Id1 can induce apoptosis in
serum-starved fibroblasts and is correlated with cell cycle progression promoted by Id family members. For example, Id2 can reverse the cell
cycle block provided by retinoblastoma protein (Rb) via direct interaction between Id2 and Rb. Clone B31.1 has been reported to recognize
mouse Id2, but does not crossreact with mouse Id1 or mouse Id3.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.