Hu TRADD Pure B36-2 100ug

产品编号：BD-556496 品牌：BD-Pharmingen 原厂货号：556496
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

100ug

运保温度:

Store undiluted at 4°C.

到货周期：

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描述：

TRADD (TNF Receptor Associated Death domain) is an ~36 kDa protein that interacts specifically with the cytoplasmic domain of the type I
TNF Receptor. Overexpression of the C-terminal 118 amino acids of TRADD, the “death domain,” is sufficient to induce two major
TNF-induced responses, apoptosis and activation of nuclear transcription factor, NF-κB. Evidence suggests that TRADD interacts with other
signal molecules including TRAF1, TRAF2 and FADD, allowing recruitment of these molecules to the TNF receptor complex. A similar
interaction has been demonstrated for TRADD and the serine/threonine kinase RIP. Coexpression of the ICE-specific protease inhibitor,
CrmA, inhibits TRADD-induced apoptosis, but does not affect induction of NF-κB, suggesting that TRADD may serve to initiate distinct
signal pathways.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.