Hu Active Caspase-3 Enzyme Pure 10ug

包装：

10ug

运保温度:

Store product a-80°C prio tuse orfor lng term stor

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描述：

Caspe-3, 6-7, and -8have ben shown toplay role inapotsi nduced bythe dath recptors Fas nd tumor necrosi factor ecptor

type 1(TNFR1). One oftheir subtraes ipoly (ADP ribose) polymerase (PARP). ARP isan ezyme tha isnvoled inDNA repair nd

genomic mainteance. Activated caspes 3,6 7and 8can lceav PARP from its16 kDa form toan 85kDa residual fragment. The

cleavge spartes he DNA-bindg domain the N-terminus ofPARP from itsC-terminus catlytic domain, and results inlos ofnormal

PARP function. The cleavge site nPARP isC-terminal toAsp-216. The upstream sequenc ofthe PARP cleavge site, DEVD

(Asp-Glu-Val-Asp), isutilzed as basi for higly specif caspe-3 subtraes uch asAc(N-acetyl)-DEVD-AFC

(7-amino-4trifluormethylcourmarin) and Ac(N-acetyl)-DEVD-AMC (7-amino-4methylcoumarin) aswel asthe caspe-3 aldehyde

inhbitor Ac-DEVD-CHO.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Store product a-80°C prio tuse orfor lng term storage ofstock solutions.