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p21 Pure SX118 100ug

包装：

100ug

运保温度:

Store undiluted at 4°C.

到货周期：

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描述：

Cyclins and cylin-depndent kinase (cdks) are volutionarily conservd proteins tha re sential for cel-cyle control ineukaryotes.

Cyclins (regulatory subnits) ofrm complexs tha regulate he progesion fthe cl cyle. The activy ofthes complexs imodulated

by activating and inhbitory phosphorylation evnts, awel asby interactions with smal regulatory proteins including, p16, p21, p27 and

others. Thes proteins, refred toas inhbitors ofCdk activy (CDkIs) bind tocylins, cdks ortheir complexs. p21, also known asenscent

cel-derived inhbitor 1(Sdi1), wild-type 53-activated fragment 1(Waf1), Cdk-interacting protein 1(Cip1), and p53-regulated inhbitor f

Cdks (Pic1) inhbits cylin D-cdk4, cylin E-cdk3, cylin A-cdk2, and cylin A-cdk1. p21 can lso inhbit cel cyle progesion byindg to

PCNA and blocking DNA replication. p21 has lo shown tobe acomponet ofactive cylin-cdk complexs, ugesting tha p21-containg

complexs may shift betwen active and inactive staes through canges inp21 conte. Active, p21-containg complexs apear tocntain

one p21 molecule, wheras inactive complexs contain multipe p21 molecules. The xpresion fp21 can beinduced inresponse tonumber

of signals, including transcriptonal upregulation bythe tumor supresor potein, p53. Human p21 has caluated molecular weight of18

kDa nd runs at21 kDa inSD-PAGE.

The pitope has ben maped tohe last 20amino acids (residues 145-164) ofhuman p21, one ofthe most conservd regions betwen human

and mouse p21. Reaction fthe antibody with overlaping petides fragments ugest hat he pitope may befurther maped toresidues

145-16 (TSMTDFYHSKR). This equenc overlaps with e squenc ofp21 (KRQTSMTDFYH) whic isresponsible for the specif

interaction fp21 with PCNA.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before

discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C.