描述：
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor, plays an important role in regulating diverse biological
processes in the central and peripheral nervous systems, the cardiovascular system and the gastrointestinal systems. The different functions of
serotonin are thought to be mediated through specific receptors. Physiological, biochemical, and pharmacological studies have defined at least
fourteen serotonin receptors. The fourteen receptors are grouped in seven subtypes according to operational, structural, and transductional
properties. The 5-HT2 receptors (5 -HT[2A]R, 5-HT[2B]R, an d 5-HT[2C]R) may be considered as prototypes for the study of serotonin
receptors . Their functions are mediated by the second messenger inositol polyphosphate in a G-protein coupled pathway. They are expressed
in diverse tissues including brain, vascular smooth muscles and platelets. The 5-HT[2A]R-mRNAs have been found in only a few areas of the
brain, including the frontal cortex, piriform cortex, ventro-caudal part of CA3, motor cranial nerve nuclei in the brainstem, and the ventral
horn of the spinal cord. The 5-HT[2C]R mRNA has been found at high levels in many parts of the brain including retrosplenial piriform and
entorhinal cortex, anterior olfactory nucleus, substantia nigra pars compacta, several brainstem nuclei and the whole grey matter of the spinal
cord. The 5-HT[2B]R was cloned in stomach fundus, where it is abundantly expressed.
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.
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