Hu CD34 FITC 581 100Tst

• 产品编号：BD-555821      品牌：BD-Pharmingen       原厂货号：555821
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

581单克隆抗体可结合CD34。CD34是一个单链105-120 kDa的高度O-糖基化跨膜糖蛋白，表达于造血祖细胞、血管内皮细胞和某些组织成纤维细胞。CD34抗原的胞内段肽链的可被活化的蛋白激酶C磷酸化，激活的提示CD34可能在信号转导中发挥作用的目标。CD34也可能在特异性抗原与内皮的粘附过程中发挥作用。581单抗可与第三类CD34表位发生反应，它是神经氨酸苷酶、木瓜凝乳蛋白酶和糖蛋白酶的拮抗剂。581抗体可封闭另一个抗CD34单克隆抗体8G12的活性。

原厂资料：

Reacts with a single-chain 105-120 kDa heavily O-glycosylated transmembrane glycoprotein expressed on a hemotopoietic progenitor cells, vascular endothelium and some tissue fibroblasts. The intracellular chain of the CD34 antigen is a target for phosphorylation by activated protein kinase C suggesting CD34 may play a role in signal transduction. CD34 may also play a role in adhesion of specific antigens to endothelium. Clone 581 reacts with the class III CD34 epitope, it is resistant to neuraminidase, chymopapain and glycoprotease. 581 blocks reactivity of another anti-CD34 monoclonal antibody, 8G12.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 X 10e6 cells in a 100-μl experimental sample (a test).
2. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4.Source of all serum proteins is from USDA inspected abattoirs located in the United States.

5.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.