Hu CD28 NALE CD28.2 500ug

产品编号：BD-555725 品牌：BD-Pharmingen 原厂货号：555725
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

500ug

运保温度:

Store undiluted at 4°C.

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描述：

CD28.2单克隆抗体特异性结合CD28。CD28是一个44 kDa的同型二聚体跨膜糖蛋白，存在于许多成熟的T细胞、胸腺细胞和浆细胞表面。CD28是一种共刺激受体，可作为配体结合CD80和CD86，在T-细胞B细胞的相互作用中起到非常重要的作用。CD28激发和调节一种单独的和独特的信号传导途径，该途径与那些由TCR复合物激发的信号传导途径不同。另外，据报道，CD28抗体的不同克隆，刺激T细胞产生IL-2和增加细胞内钙离子浓度的能力各不相同。这一发现表明，CD28分子存在不同的功能亚区。已经证实CD28.2单抗与另一个CD28单克隆抗体（克隆L293）可结合同一种蛋白分子。并且有报道指出，CD28.2单抗可引发Jurkat T细胞的Ca2+注入。

原厂资料：

The CD28.2 monoclonal antibody specifically binds to CD28, a 44 kDa homodimeric transmembrane glycoprotein present on most mature T cells, thymocytes and plasma cells. CD28 is a costimulatory receptor that binds CD80 and CD86 as ligands and plays a very important role in T cell-B cell interactions. It has been suggested that CD28 initiates and regulates a separate and distinct signal transduction pathway from those stimulated by the TCR complex. Additionally, it has been reported that CD28 antibody clones vary in their ability to stimulate T cells to produce IL-2 and increase intracellular Ca2+ concentration. This finding suggests the existence of functionally distinct subregions on the CD28 molecule. CD28.2 has been demonstrated to bind to the same molecule as clone L293, another CD28 mAb, and has been reported to induce Ca2+ influx in Jurkat T cells.

注意事项：

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Store undiluted at 4°C.