Ms CD70 PE FR70 100ug

产品编号：BD-555286 品牌：BD-Pharmingen 原厂货号：555286
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

100ug

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The FR70 antibody reacts with mouse CD70, a 30-33-kDa type-II transmembrane glycoprotein belonging to the TNF/NGF superfamily.

CD70 is the ligand for CD27 and is expressed primarily on activated B cells. CD70 expression can be induced by activation of splenocytes

with Lipopolysaccharide, anti-IgM, anti-mouse CD40 mAb HM40-3 (Cat. no. 553721) or 3/23 (Cat. no. 553787), or anti-IgM plus

anti-CD40, but not Concanavalin A or immobilized anti-mouse CD3e mAb 145-2C11 (Cat. no. 553057) plus soluble anti-CD28. IL-4 may

be a negative regulator of CD70 expression by B cells. Cd70 mRNA is transiently expressed after ConA stimulation of splenocytes or

thymocytes. CD70 was observed on dendritic cells of mice infected with Leishmania major; however, its level of expression on dendritic cells

of naive mice was not reported. The CD27-CD70 interaction delivers T-cell1, and NK-cell costimulatory signals. It has been reported that

FR70 mAb blocks binding of mCD27-Ig fusion protein to mCd70-transfected cells and inhibits some in vitro T-cell- and NK-cell-dependent

responses.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

4.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

5.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.