Rat CD161a NKR-P1A FITC 10/78 500ug

产品编号：BD-555008 品牌：BD-Pharmingen 原厂货号：555008
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

500ug

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The 10/78 antibody reacts with NKR-P1A, a 60-kDa homodimer expressed on all natural killer (NK) cells and a small subset of T

lymphocytes. The 10/78 antibody competes with the previously described 3.2.3 antibody for binding to the antigen. NKR-P1A is a type-II

integral membrane protein with an extracellular C-type lectin domain, which is an NK cell-activating receptor specific for tumor target cells.

Many rat dendritic cells have been shown to express NKR-P1A, and a subpopulation of these cells has cytotoxic activity. NKR-P1A has also

been detected at low levels on peripheral blood monocytes, and its expression is upregulated in IFN-γ-activated monocytes, specifically in a

subpopulation of large monocytes with phagocytic capacity. Furthermore, activated peripheral blood neutrophils may express a low level of

NKR-P1A. In the mouse and rat, three members of the NKR-P1 gene family have been identified; but in the human gene family, a single

NKR-P1 homologue has been discovered and designated Cd161.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

4.The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.

5.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.