Bta PDGFR Tail Serum Poly 1036 0.1mL

• 产品编号：BD-554288      品牌：BD-Pharmingen       原厂货号：554288
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Platelet derived growth factor (PDGF) plays a role in regulating a number of biological processes including cellular proliferation and
development through signal transduction. PDGF consists of homo- or heterodimers of two chains, A and B, which are encoded by two
separate genes. The three possible combinations of the PDGF chains, AA, AB, and BB are all biologically active. The PDGF receptor
(PDGFR) is a protein tyrosine kinase. Ligand binding to the PDGFR leads to tyrosine phosphorylation of numerous intracellular proteins,
including the receptor itself. The PDGFR consists of two subunits, α and β, which are encoded by two separate genes. The α subunit binds to
both the A and B PDGF chains with high affinity, whereas the β subunit binds only to the B chain with high affinity. Ligand binding results in
receptor dimerization, with the PDGF type (AA, AB, or BB) influencing the resulting PDGFR subunit composition (αα, αβ, or ββ). That is,
PDGF-AA binds to αα receptors, PDGF-AB binds to αα and αβ receptors, and PDGF-BB binds to αα, αβ, or ββ receptors. This polyclonal
antibody has been reported to recognize both mouse and human βPDGFR. The immature and mature forms of the βPDGFR subunit have been
reported to be observed by SDS-PAGE migrating at 160 and 180 kDa, respectively.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.