PDGF-AB/BB Pure Sis1 100ug

• 产品编号：BD-554284      品牌：BD-Pharmingen       原厂货号：554284
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Platelet derived growth factor (PDGF) plays a role in regulating a number of biological processes including cellular proliferation and
development. PDGF consists of a disulfide-linked homo- or heterodimer of two chains, A and B, which are encoded by two separate genes.
The three possible combinations of the PDGF chains, AA, AB, and BB, are all biologically active. The PDGF receptor (PDGFR) is a protein
tyrosine kinase. Ligand binding to the PDGFR leads to tyrosine phosphorylation of numerous intracellular proteins, including the receptor
itself. The PDGFR consists of two subunits, α and β, which are encoded by two separate genes. The α subunit binds to both the A and B
PDGF chains with high affinity, whereas the β subunit binds only to the B chain with high affinity. Ligand binding results in receptor
dimerization, with the PDGF type (AA, AB or BB) influencing the resulting PDGFR subunit composition (αα, αβ, or ββ). That is, PDGF-AA
binds to αα receptors, PDGF-AB binds to αα and αβ receptors, and PDGF-BB binds to αα, αβ, and ββ receptors. This antibody reportedly
recognizes B chain-containing human PDGF isoforms and does not recognize the PDGF-AA homodimer. Additionally, this antibody
reportedly inhibits PDGFR binding of PDGF-AB and -BB, but not PDGF-AA and is thought to recognize a conformational epitope of the
PDGF B chain that is dependent on disulfide linkages. This antibody has been reported to inhibit PDGF receptor-binding and mitogenic
effects of PDGF-AB and -BB.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.