Hu p21 Pure 2G12 100ug

• 产品编号：BD-554262      品牌：BD-Pharmingen       原厂货号：554262
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The p21 protein belongs to a class of tumor suppressors including p16 and p27 which control progression through the cell cycle by inhibiting
the activity of cyclin-cdk complexes. p21 is also known as senescent cell-derived inhibitor 1 (Sdi1), wild-type p53-activated fragment 1
(Waf1), Cdk-interacting protein 1 (Cip1), p21, and p53-regulated inhibitor of Cdks (Pic1). The 2.1 kb cDNA coding for p21 was first cloned
from a library made from senescent normal human foreskin fibroblasts. When introduced into proliferating foreskin fibroblasts it causes
inhibition of DNA synthesis and cell cycle arrest. The p21 mRNA is expressed at higher levels in senescent fibroblasts than in actively
growing cells. The resultant protein has a calculated molecular weight of 18 kDa and runs at 21 kDa in SDS/PAGE. p21 is believed to
function by inhibiting the kinase activity of the cyclin-cdk complexes to which it binds. p53 has been shown to cause the induction of p21
gene, presumably by recognizing a p53 binding site identified in the promoter of the p21 gene. Clone 2G12 recognizes human p21. A
full-length human p21 fusion protein was expressed in bacteria and used as immunogen. Mice were immunized and hybridomas were selected
for reactivity against p21 by ELISA and western blot analysis.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.