Hu Androgen Rcptr Pure G122-434 100ug

产品编号：BD-554225 品牌：BD-Pharmingen 原厂货号：554225
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

100ug

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The androgen receptor (AR) mediating androgen effects is a member of the steroid and thyroid hormone receptor gene superfamily encoding
liganddependent nuclear transcription factors. They can be divided into three main domains, an N-terminal domain which modulates
transcription efficiency, a central DNA domain which binds to a target gene hormone response element, and a C-terminal hormone binding
domain. Androgens are necessary for normal male development and function. They exert their effects on target tissue through binding to the
AR, followed by association of the AR complex with specific binding sites on DNA. This AR complex may induce or repress gene
transcription. Mutations in the AR gene are associated with androgen insensitivity syndrome, a disorder that causes XY genotypic males to
develop as phenotypic females because of their inability to respond to androgens. AR mutations have also been identified in human prostate
cancer specimens and the LNCaP human prostate cancer cell line. Monoclonal and polyclonal antibodies to the AR have identified
AR-positive cells in a variety of tissues including male and female sexual organs, kidney, liver, adrenal cortex, pituitary gland, skeletal,
cardiac, and smooth muscle cells. The androgen receptor has been identified as a 100 kDa protein in SDS/PAGE. G122-434 recognizes an
epitope localized within the N-terminal domain (between amino acids 33 and 485) of the human androgen receptor protein. The antibody does
not recognize estrogen or progesterone receptors. Purified recombinant human androgen receptor protein was used as immunogen.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.