Hu DCC Pure G92-13 100ug

• 产品编号：BD-554222      品牌：BD-Pharmingen       原厂货号：554222
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

One of the most common regions of allelic loss in colorectal tumors is chromosome 18, which is lost in more than 70% of carcinomas, and in
almost 50% of late adenomas. This region of loss has been mapped to chromosome 18q and a gene called Deleted in Colorectal Cancer
(DCC). DCC encodes an ~185 kD glycoprotein with significant homology to the neural cell adhesion molecule and other related cell surface
glycoproteins. The predicted amino acid sequence of DCC cDNA consists of a 1448 amino acid (aa) long transmembrane phosphoprotein. The
extracellular domain consists of 1098 amino acids and has 42% sequence homology to cell adhesion proteins of the neural cell adhesion
molecule (N-CAM) family. DCC mRNA is found to be expressed in normal colonic mucosa, but its expression is reduced or absent in the
majority of colorectal carcinomas. The loss of heterozygosity and subsequent alteration of DCC expression has also been observed in tumors
of non-colorectal origin. G92-13 recognizes human DCC. A truncated recombinant protein containing the extracellular domain of the human
DCC was used as immunogen.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.