Ms CD28 NALE 37.51 500ug

产品编号：BD-553294 品牌：BD-Pharmingen 原厂货号：553294
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

500ug

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

37.51抗体与CD28。在脾细胞和胸腺细胞在活化后可增加CD28的表达。CD28是一种共刺激受体，其配体包括CD80（B7-1）和CD86（B7-2）。CD28转录被发现在肥大细胞，和CD28的细胞表面表达被诱导时成熟或活化的肥大细胞。据报道，CD28不表达于上皮内淋巴细胞的一些种群。37.51单抗增可上调细胞增殖，提高活化的T和NK细胞的细胞因子产生能力，并能提供诱导CTL的共刺激信号。有相当多的证据表明，CD28作为一种协同刺激受体，参与许多T细胞依赖的免疫应答。

原厂资料：

The 37.51 antibody reacts with CD28, which is expressed on most thymocytes, at low density on nearly all CD4+ and CD8+ peripheral T cells, and at even lower density on NK cells. The expression of CD28, in splenocytes and thymocytes, has been reported to increase after activation. CD28 transcripts are found in mast cells, and cell-surface expression of CD28 is induced upon maturation or activation of mast cells. It has been reported that CD28 is not expressed on some populations of intraepithelial T lymphocytes. CD28 is a costimulatory receptor; its ligands include CD80 (B7-1) and CD86 (B7-2). The 37.51 mAb augments proliferation and cytokine production by activated T and NK cells and can provide a costimulatory signal for CTL induction. There is considerable evidence that CD28 is a costimulatory receptor involved in many, but not all, T cell-dependent immune responses.

注意事项：

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Store undiluted at 4°C.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
This preparation contains no preservatives, thus it should be handled under aseptic conditions.