AHP799 recognises the 250kD protein product of KIAA0170, recently named MDC1 (for mediator of DNA damage checkpoint protein 1).
Research suggest that MDC1 is involved in the early stages of response to DNA damage and may recruit other factor to sites of DNA damage.
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
ELISA
Flow Cytometry
Immunofluorescence
1/500
Immunohistology - Frozen
Immunohistology - Paraffin
Immunoprecipitation
Western Blotting
1/2000
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own systems using appropriate negative/positive controls.
Western Blotting
AHP799 detects 3 bands of approximately 250 kDa in HeLa and 293T cell lysates.
Storage
Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended.
Shelf Life
18 months from date of despatch.
Antiserum Preparation
Antisera to human MDC1 (3838) were raised by repeated immunisations of sheep with highly purified antigen.
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