AHP385T reacts with human S-100 A and S-100 B. This protein is present in brain glial cells and in ependymal cells. AHP385T also stains Schwann cells of the peripheral nervous system.
Among tumours of the human central and peripheral nervous systems, schwannomas, ependymomas and astrogliomas of different stages, including glioblastomas show positive reactions. S100 can be detected in almost all benign naevi and malignant melanocytic tumours of the skin and in Langerhans cells in the skin.
Species Cross-Reactivity
Target Species
Cross Reactivity
Human
Yes
Mouse
Yes
Rat
Yes
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
Immunohistology - Frozen
1/10 - 1/40
Immunohistology - Paraffin
1/10 - 1/40
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Immunohistology
This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
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