AHP1748 recognises human alpha 1 acid glycoprotein (alpha 1-AGP), also known as orosomucoid (ORM1), a 40kDa major acute phase reactant secreted into the plasma by the liver, believed to act as an anti-inflammatory and immunomodulatory agent.
An increase in plasma alpha 1-AGP levels occurs during tissue injury, inflammation, infection, surgery, acute myocardial infarction, trauma and pregnancy. Regulators of alpha 1-AGP expression include IL-1beta, IL-6, glucocorticoids, TNF-alpha and retinoic acids, and alpha 1-AGP can bind to drugs from endogenous and exogenous origin.
This reagent is available in bulk quantities and may be made available in other formats. Please enquire for further details.
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
Turbidimetry
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.
Antiserum Preparation
Antisera to human Alpha 1 Acid Glycoprotein were raised by repeated immunisation of goats with highly purified antigen.
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