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RABBIT ANTI HUMAN INTERLEUKIN-23 (N-TERMINAL)

  • 产品编号:AHP1174      品牌:AbD Serotec       原厂货号:AHP1174
  • 产品分类:抗体 > 一抗 > 蛋白特异性一抗
  • 应用分类:
 
包装: 0.1 mg
运保温度: +4oC or -20oC
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描述:

Specificity

AHP1174 detects an epitope within the N-terminal (NT) domain of human interleukin-23 (IL-23), a 21kD heterodimeric cytokine structurally related to IL-12. IL-23 is composed of a p19 subunit encoded by the IL23A gene, and a p40 subunit of interleukin-12 (IL12B). IL-23 is expressed mainly by activated macrophages and dendritic cells, and plays an important role in bridging innate and adaptive responses.

IL-23 activates a subset of T cells called Th17 cells, which are characterised by the production of interleukin-17. The IL-23/IL-17 pathway is essential for the induction and maintenance of brain and joint inflammatory autoimmune diseases, including Guillain Barre Syndrome, Multiple sclerosis and rheumatoid arthritis.

Species Cross-Reactivity

Target Species Cross Reactivity
Mouse Yes

Application

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.

 

Application Name Yes No Not Determined Suggested Dilution
ELISA        
Flow Cytometry        
Immunohistology - Frozen        
Immunohistology - Paraffin        
Immunoprecipitation        
Western Blotting       1 - 2ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Western Blotting

AHP1174 detects a band of approximately 24kDa in mouse pancreas tissue lysate.

Storage

Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Shelf Life

18 months from date of despatch.

Antiserum Preparation

Antisera to human IL-23 (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

GO Terms

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说明书

参考文献

本产品可用于的实验

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