MO TSLP UNCOATED ELISA

• 产品编号：88-7490-88      品牌：invitrogen       原厂货号：88-7490-88
• 产品分类：ELISA及其它免疫分析 > ELISA > ELISA检测试剂盒
• 应用分类：

描述：

Description: This Mouse TSLP ELISA Ready-SET-Go! reagent set contains all of the necessary buffers and reagents to perform enzyme-linked immunosorbent assays. The set has been optimized for the accurate and precise measurement of mouse TSLP in serum, and tissue culture supernatant samples.

TSLP (Thymic Stromal-Derived Lymphopoetin) was first identified in the tissue culture supernatant of a thymic stromal cell line as a growth factor capable of inducing proliferation and differentiation of pre-B cells. It was later found to be closely related to another stromal cytokine, IL-7, with which it shares overlapping functions. Along with its proliferative effects on B cells, TSLP induces dendritic cells to support the differentiation of naïve T cells towards the Th2 lineage and may also be involved in the development of CD4⁺CD25⁺ regulatory T cells. The receptor is heterodimeric and shares one subunit, IL-7R alpha, with IL-7 and other members of the family, while the TSLPR subunit is unique to TSLP.

TSLP expression can be induced by a variety of inflammatory cytokines and TLR ligands. Expression is regulated by NF kappa B and has been detected in epithelial cells, stromal cells, and basophils. Elevated levels of TSLP are associated with asthma and atopic dermatitis, which are both Th2-mediated inflammatory conditions. It is believed that chronic overexpression of TSLP may result in increased sensitivity to allergens, resulting in susceptibility to these conditions.

原厂资料：