7440-0104F recognises human plasminogen, a 92kDa single-chain glycoprotein and inactive precursor (zymogen) of plasmin, secreted by the liver and present in the blood and majority of extravascular body fluids.
Plasminogen is the central component in the fibrinolytic system, and is converted into active plasmin through cleavage by the endogenous activators urokinase (u-PA) and tissue plasminogen activator (t-PA), in the presence of fibrin. The level of plasminogen is maintained in the plasma at around 200mg/L, with an increase being associated with hypothyroidism, obesity and pregnancy, and deficiencies with many disorders including thrombosis, liver disease, sepsis and hyperthyroidism.
7440-0104F may cross react with plasminogen from other species.
Species Cross-Reactivity
Target Species
Cross Reactivity
Bovine
Yes
Cat
Yes
Dog
Yes
Guinea Pig
Yes
Rat
Yes
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
Immunofluorescence
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.
Antiserum Preparation
Antisera to human plasminogen were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG prepared by affinity chromatography.
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