The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of rat BimEL that contains serine 65 (serine 69 in the human sequence). The sequence is conserved in human and mouse.
Conjugate
Unconjugated
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.3, with 1mg/ml BSA, 50% glycerol
Contains
0.05% sodium azide
Storage Conditions
-20°C
Tested Applications
Dilution *
Western Blot (WB)
Assay Dependent
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Background/Target Information
Bcl-2 (B-cell lymphoma) and close homologues promote cell survival while many of its relatives lead to apoptotic cell death. The Bcl-2 homology 3 (BH3) domain is a potent death domain, and a novel BH3 domain containing protein, termed Bim or BOD (Bcl-2-related Ovarian Death Gene), has recently been cloned. Bim possesses a hydrophobic C-terminus and is localized to the intracytoplasmic membranes. Bcl-2 binds to Bim and modulates its death function, while Bcl-2 mutants are unable to do either.
原厂资料：
注意事项：
For Research Use Only. Not for use in diagnostic procedures.
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