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PHOSPHO-JAK2 PAB 100 UL BIOSOURCE (TM)

 
包装:
运保温度: Store at -20
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描述:

 

Details
Tested species reactivity Human , Mouse , Rat
Published species reactivity Rat , Primate , Mouse , Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of mouse JAK2 that contains tyrosines 1007 and 1008.
Conjugate Unconjugated
Form Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.3, with 1mg/ml BSA, 50% glycerol
Contains 0.05% sodium azide
Storage Conditions -20°C
Tested Applications Dilution *
Western Blot (WB) Assay Dependent

* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

Published Applications  
Western Blot (WB) See 15 publications below

Background/Target Information

Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.

 


注意事项:


For Research Use Only. Not for use in diagnostic procedures.
 


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